CBT4CBT FOR ALCOHOL OR OPIOID USE DISORDER

DESCRIPTION: CBT4CBT (computer-based training for cognitive-behavioral therapy) is a seven-module computerized training in cognitive behavioral therapy. The proposed pilot study will examine the feasibility and acceptability of CBT4CBT in office-based medication treatment of opioid and alcohol use disorders. OUTCOMES: Though this study has completed enrollment, data analysis is still underway. Results will be posted here once available.

Read More

Determining the Efficacy of Cognitive-Behavioral Motivational Enhancement +/- Nicotine Replacement Therapy for Adolescents

DESCRIPTION: In order to develop a tailored, practical, and efficacious smoking cessation intervention that starts with a behavioral platform and offers the potential for pharmacotherapy (in this instance, nicotine transdermal therapy using Nicoderm CQ®), 84 subjects ages 14-21 were recruited for this 24-week study. Participants reported smoking at least 5 cigarettes daily in the month before entry into the study and initiation of smoking at least 6 months before entry. All youth received 6 weeks…

Read More

HIV/STD Risk Behaviors in Methamphetamine User Networks — Main Study

DESCRIPTION: Funded by the National Institute on Drug Abuse (U01 DA017394), this project was a part of the SATHCAP (Sexual Acquisition and Transmission of HIV Cooperative Agreement program). The primary purpose of the main study was to determine the extent to which HIV infections spread through drug-related and sexual transmission behaviors. We also sought to identify the individual, network, and structural characteristics that influence the speed, extent and path of transmission. Learn more about the…

Read More

HPTN 073: PRE-EXPOSURE PROPHYLAXIS UPTAKE AND ADHERENCE AMONG BLACK MEN WHO HAVE SEX WITH MEN (BMSM)

DESCRIPTION: This is a collaborative project of the national HIV Prevention Trials Network (HPTN), protocol #073 (HPTN 073). The trial will test Truvada®, an HIV treatment medication, for pre-exposure prophylaxis (PrEP). PrEP is a new HIV prevention method in which people who are HIV-negative can be prescribed a daily HIV treatment drug to reduce their risk of becoming infected. The FDA approved Truvada® for use as PrEP in 2012. The Los Angeles site will enroll…

Read More

HPTN061: The BROTHERS Study (Broadening the Reach of Testing, Health Education, Resources and Services for Black Men Who Have Sex With Men)

DESCRIPTION: The BROTHERS study, a project of the HIV Prevention Trials Network (HPTN), aimed to see if certain strategies can show promise for slowing down the spread of HIV among Black men who have sex with men (Black MSM). Another aim is to better understand the men’s lives and how that relates to HIV risk. OUTCOMES: The overall rate of new HIV infection among Black MSM in this study was 2.8% per year, a rate that is nearly…

Read More

HPV in MA Using and Non-Using MSM in LA — Supplemental Study

DESCRIPTION: This was a sub-study of the project “HIV/STD Risk Behaviors in Methamphetamine User Networks”. It sought measure the prevalence anal human papillomavirus (HPV) among HIV-negative MSM who use methamphetamine compared to those who do not use methamphetamine. OUTCOMES: The supplemental project extends the breadth of research findings in the main study by documenting that the primary drivers of high-risk anal HPV are linked to HIV-infection, MSMW behaviors, and being African American. Use of methamphetamine…

Read More

Methamphetamine-Associated Factors in Recent and Chronic Infection in MSM in Los Angeles — Supplemental Study

DESCRIPTION: This was a sub-study of the project “HIV/STD Risk Behaviors in Methamphetamine User Networks”. The purpose of the project was to assess the characteristics of the HIV virus in methamphetamine-using MSM that may be associated with efficient transmission of new infections. These characteristics include viral load, genotype, extent of treatment. We also sought to evaluate the behavioral similarities between individuals with treatment-resistant strains of HIV such as their patterns of methamphetamine use, sexual practices,…

Read More

Methods of Using Real-Time Social Media Technologies for Detection and Remote Monitoring of HIV Outcomes — Supplemental Study

DESCRIPTION: This study sought to establish methods of using real-time social networking data for HIV prevention by assessing 1) whether geolocated conversations about HIV risk behaviors can be extracted from social networking data, 2) the prevalence and content of these conversations, and 3) the feasibility of using HIV risk-related real-time social media conversations as a method to detect HIV outcomes. OUTCOMES: Over 9800 geolocated tweets were extracted and used to create a map displaying the…

Read More

Molecular Epidemiology of HIV in MA Using and Non-Using MSM, MSM/W and Their Partners in LA — Supplemental Study

DESCRIPTION: This was a sub-study of the project “HIV/STD Risk Behaviors in Methamphetamine User Networks”. The purpose this project was to investigate epidemiological clustering of HIV as revealed by viral phylogenetic analysis to support or refute epidemiological linkage of pairs of HIV infected individuals, to describe broad patterns of clustering of infections by ethnic group and by structural features, and to describe the epidemiology of drug resistant HIV within this population OUTCOMES: In our initial…

Read More

PERCEPTIONS OF AND INTENTIONS TO ADOPT HIV PRE-EXPOSURE PROPHYLAXIS AMONG BLACK MEN WHO HAVE SEX WITH MEN IN LOS ANGELES.

DESCRIPTION: This study assessed perceptions of pre-exposure prophylaxis (PrEP) and their association with PrEP adoption intention among a convenience sample of 224 low socioeconomic status Black men who have sex with men (BMSM) residing in Los Angeles. Participants received educational information about PrEP and completed an in-person interview. OUTCOMES: More than half of the participants indicated a high intention to adopt PrEP. BMSM (18-29 years) were twice as likely to report a high intention to…

Read More

Pharmacogenomics and Anti-Addiction Medication Development

DESCRIPTION: Genetic differences are thought to be an important biological predictor of response to treatment for addiction. The purpose of this project was to identify genetic factors influencing addiction severity and response to anti-addiction medications, with an emphasis on medications to treat methamphetamine dependence. We collected DNA specimens from a sample of well-phenotyped methamphetamine users who were participating in our clinical studies, including a pharmacogenetic clinical trial of bupropion for methamphetamine dependence. This outpatient study…

Read More

Phase I Safety Interaction Trial of Ibudilast with Methamphetamine

DESCRIPTION: To date, no medications have been approved expressly for the treatment of methamphetamine dependence, leaving few options for doctors and patients battling this particular addiction. This clinical trial sought to determine the safety and tolerability of the medication ibudilast in non-treatment seeking, methamphetamine-dependent volunteers.The study took place at the Harbor-UCLA Medical Center in Torrance. OUTCOMES: Though this study has completed enrollment, data analysis is underway. Preliminary outcomes of the trial were presented at the…

Read More

Phase II Randomized, Double-Blind Controlled Trial of HORIZANT® for Alcohol Use Disorder

RELEVANCE: Alcohol Use Disorder (AUD) affects 18 million Americans, and is linked to 80,000 deaths a year, presenting a staggering $224 billion dollar economic loss to society. Yet, there are only four medications approved by the FDA to treat AUD. DESCRIPTION: The primary objective of this study is to compare the efficacy of HORIZANT® with a placebo on individuals with AUD. The secondary objectives are to assess other treatment benefits such as reduction in alcohol…

Read More

Phase II Randomized, Double-Blind Controlled Trial of HORIZANT® for Alcohol Use Disorder

RELEVANCE: Alcohol Use Disorder (AUD) affects 18 million Americans, and is linked to 80,000 deaths a year, presenting a staggering $224 billion dollar economic loss to society. Yet, there are only four medications approved by the FDA to treat AUD. DESCRIPTION: The primary objective of this study is to compare the efficacy of HORIZANT® with a placebo on individuals with AUD. The secondary objectives are to assess other treatment benefits such as reduction in alcohol…

Read More

Pilot Randomized Trial of Bupropion for Adolescent Methamphetamine Abuse/Dependence

DESCRIPTION: The purpose of this pilot clinical trial was to determine the safety of bupropion for methamphetamine abuse/dependence among adolescents. Nineteen adolescents were randomly assigned to bupropion sustained release 150mg twice daily or placebo for 8 weeks in addition to outpatient substance abuse counseling. OUTCOMES: Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Those participants who received bupropion and females in the…

Read More

Randomized, Placebo-Controlled Trial of Bupropion for the Treatment of Methamphetamine Dependence

Randomized, placebo-controlled trial of bupropion for the treatment of methamphetamine dependence DESCRIPTION: This study sought to compare bupropion to placebo for reducing methamphetamine (MA) use, increasing retention, and reducing the severity of depressive symptoms and MA-cravings. Additionally, a secondary objective compared bupropion to placebo for reducing cigarette smoking among MA dependent participants. Following a 2-week, non-medication baseline screening period, 73 treatment-seeking MA dependent participants were randomly assigned to bupropion sustained release (150 mg twice daily;…

Read More

USING ONLINE SOCIAL NETWORKS FOR HIV PREVENTION IN AFRICAN AMERICAN/LATINO MSM

DESCRIPTION: This randomized trial is designed to test the feasibility of using social networking technologies for HIV prevention among African American and Latino men who have sex with men (MSM) in Los Angeles. Findings from this study will be used to prepare for a larger intervention to assess whether online social networking technologies can be used for HIV prevention among high-risk populations. OUTCOMES: Further analysis is underway. Several publications have utilized data collected from this…

Read More

Using Social Media with Latino Men Who Have Sex with Men for HIV Testing and Linkage

RELEVANCE: In Los Angeles County Latinos comprise approximately 50% of all annually reported HIV infections, and Latino men who have sex with men (MSM) make up 85% of all HIV infections among Latinos. Identifying innovative ways of engaging Latino MSM in HIV testing, medical care, and prevention services has the potential to decrease HIV transmission among this population and improve health outcomes of those living with HIV. DESCRIPTION: We propose to develop a culturally-tailored intervention…

Read More

VARENICLINE FOR METHAMPHETAMINE DEPENDENCE

DESCRIPTION: The goal of this Phase II study is to test the early efficacy of the medication varenicline in treating methamphetamine dependence. The safety and tolerability of varenicline for the treatment of methamphetamine was tested previously and pilot data on the medication’s effectiveness was found to be promising. OUTCOMES: Varenicline was well tolerated, but was not found to be universally efficacious for achieving MA abstinence in this Phase 2 clinical trial. 1. Briones M, Worley…

Read More