DESCRIPTION: Genetic differences are thought to be an important biological predictor of response to treatment for addiction. The purpose of this project was to identify genetic factors influencing addiction severity and response to anti-addiction medications, with an emphasis on medications to treat methamphetamine dependence. We collected DNA specimens from a sample of well-phenotyped methamphetamine users who were participating in our clinical studies, including a pharmacogenetic clinical trial of bupropion for methamphetamine dependence. This outpatient study for treatment seeking, methamphetamine-dependent persons has been completed and we are analyzing the samples and data collected.

OUTCOMES: Though this study has completed enrollment, data analysis is still underway. Results will be posted here once available.