Methamphetamine use is a growing global concern that has hampered efforts to address opioid use disorder and HIV infection. Evidence-based behavioral interventions (EBIs) to reduce methamphetamine exist, but current research on optimal EBI combinations to reduce methamphetamine use is limited. In Vietnam, methamphetamine co-use is prevalent in people receiving methadone maintenance treatment (MMT) for opioid use disorder. In response to this co-epidemic, CBAM’s Drs. Michael Li and Steve Shoptaw are collaborating with Dr. Giang Le of Hanoi Medical University to test a type-1 effectiveness-implementation hybrid design of EBIs to reduce methamphetamine use among patients from multiple MMT clinics in Vietnam. This article details the study design, procedures, implementation strategies, challenges, and planned analysis to ascertain effects on methamphetamine use, HIV viral suppression, and HIV risk behaviors. Findings may inform effectiveness and future scale-up of EBI combinations for methamphetamine use reduction among MMT patients, especially in underserved communities.
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